Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice.

• Tác giả: Jianpiao Cai, Jasper Fuk-Woo Chan, Honglin Chen, Yanxia Chen, Hin Chu, Howard Chun-Ho Chung, Kin-Hang Kok, Alvin Hiu-Chung Lam, Andrew Chak-Yiu Lee, Can Li, Xiang Yong Oong, Wenchen Song, Pui Wang, Na Xiao, Zhanhong Ye, Shuofeng Yuan, Kwok-Yung Yuen, Anna Jin-Xia Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Emerging microbes & infections , 2025
• Bộ sưu tập: NCBI
• ID: 717828

Tóm tắt

The newly emerged avian influenza A H5N1 Clade 2.3.4.4b can infect dairy cows and shed live virus in their milk. Sporadic cattle-to-human infections have been reported, highlighting the urgent need to understand its pathogenesis in mammals. Using both non-lactating and lactating BALB/c mice, we examined the viral tissue tropism, histopathological damages, and host immune responses upon intranasal inoculation with a reverse-genetic virus constructed based on A/dairy cattle/Texas/24-008749-003/2024 (Cattle-H5N1) and comparing with an older reference Clade 1 virus, A/Vietnam/1194/2004 virus (VNM1194-H5N1). Cattle-H5N1 was highly lethal in mice (mLD