Frequency and Clinical Significance of Clonal and Subclonal Driver Mutations in High-Risk Neuroblastoma at Diagnosis: A Children's Oncology Group Study.

• Tác giả: Rochelle Bagatell, Esther R Berko, Lulu Chen, Alexander A Daniels, Todd Druley, Steven G DuBois, Meredith S Irwin, Balakrishna Koneru, Kateryna Krytska, John M Maris, Samantha N McNulty, Yael P Mossé, Arlene Naranjo, Julie R Park, Grace Polkosnik, C Patrick Reynolds, Kirstin Zelley
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2025
• Bộ sưu tập: NCBI
• ID: 717837

Tóm tắt

PURPOSE: Relapsed high-risk neuroblastomas (NBLs) are enriched for targetable mutations in METHODS: We developed a focused high-risk NBL sequencing panel including CONCLUSION: Ultra-deep sequencing of high-risk NBLs demonstrates that oncogenic aberrations are more prevalent at diagnosis than previously recognized.