Revisiting toxins with transcriptomics-informed proteomics of venom glands and crude venom from Centruroides bicolor from Panama.

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Tác giả: Hildaura Acosta, John Cleghorn, Herlinda Clement, Gerardo Corzo, Sergio Encarnación-Guevara, Magdalena Hernández-Ortiz, Marcos H Salazar, Octavio Samudio

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Netherlands : Journal of proteomics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 717853

The sting of the scorpion Centruroides bicolor causes a large morbidity in Panama. To characterize its venom, transcriptomic and proteomic analyses of the venom glands and the crude venom were performed. These two approaches utilized high-throughput sequencing to enhance the likelihood of detecting a wide range of venom proteins correlated with the venom proteome. After RNA venom gland extraction, a cDNA library was constructed and sequenced by RNA-seq. Also, the crude venom was digested using trypsin and chymotrypsin, and the resulting peptides were analyzed using a nano-LC-MS/MS. Notably, transcriptomic and proteomic venom approaches identified a hyaluronidase, alpha- and beta-neurotoxins that affect Na
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