Unprecedented Alkylation of the Catalytic Histidine in the Aging of Cholinesterases after Inhibition by Organophosphorus Pesticides.

• Tác giả: Stacey K Allen, Christopher S Callam, Christopher M Hadad, Yiran He, Craig A McElroy, Kevin A Miller
• Ngôn ngữ: eng
• Ký hiệu phân loại: 584.353 *Alstroemeriaceae
• Thông tin xuất bản: United States : Chemical research in toxicology , 2025
• Bộ sưu tập: NCBI
• ID: 717887

Tóm tắt

Organophosphorus (OP) compounds pose a serious risk to human health by covalently modifying acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Currently approved oxime therapeutics can reactivate OP-inhibited AChE and BChE, despite significant limitations. The OP-inhibited enzymes undergo a secondary