Pre-clinical model of dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis.

• Tác giả: Amanda K Casey, Bret M Evers, Hazel A Fields, Hillery F Gray, Kim Orth, Carlos A Pinzon-Arteaga, Masahiro Sakurai, Nathan M Stewart, Jun Wu, Naqi Zaidi
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Molecular metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 717975

Tóm tắt

The bi-functional enzyme FicD catalyzes AMPylation and deAMPylation of the endoplasmic reticulum chaperone BiP to modulate ER homeostasis and the unfolded protein response (UPR). Human hFicD with an arginine-to-serine mutation disrupts FicD deAMPylation activity resulting in severe neonatal diabetes. We generated the mFicD