Sustainable, catalytic hybrid nano-carrier (microspheres/films) were synthesized by combining polysaccharides and silver nanoparticles (AgNPs). Chitosan (CS) and microcrystalline cellulose (MCC) acted as stabilizers and reinforcements, respectively, resulting in a bio-composite support with tailored catalytic activity. The hybrid nano-carriers were characterized using various analytical techniques including, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The catalytic performance and stability of the prepared nano-carriers (both microspheres and films) were evaluated in the synthesis of azo compounds. The results demonstrated high catalytic efficiency (up to 90 % conversion) in the production of azobenzene, with good recyclability. This study highlights the potential of chitosan, silver nanoparticles and microcrystalline cellulose as effective components in the development of catalytic nano-carriers for azo compounds synthesis.