Discovery of bifunctional small molecules targeting PD-L1/VISTA with favorable pharmacokinetics for cancer immunotherapy.

• Tác giả: Jianjun Chen, Binbin Cheng, Hao Liu, Chuxiao Shao, Yaru Shi, Wubing Tang, Shuanghu Wang, Yao Xiao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 718037

Tóm tắt

In this work, we designed and synthesized a series of bifunctional PD-L1/VISTA (V-domain immunoglobulin suppressor of T-cell activation) small molecule inhibitors. Among them, S8 showed acceptable PD-L1 inhibitory effects (IC