From Unprintable Peptidic Gel to Unstoppable: Transforming Diphenylalanine Peptide (Fmoc-FF) Nanowires and Cellulose Nanofibrils into a High-Performance Biobased Gel for 3D Printing.

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Tác giả: Jörn Appelt, Enguerrand Barba, Shouzheng Chen, Feras Dalloul, Linnea Hesse, Fabio Hubel, Sarathlal Koyiloth Vayalil, J Benedikt Mietner, Dennis M J Möck, Peter Müller-Buschbaum, Julien R G Navarro, Andrea Olbrich, Dhanya Raveendran, Stephan V Roth, Benedikt Sochor

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : ACS applied bio materials , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 718090

The growing interest in gel-based additive manufacturing, also known as three-dimensional (3D) gel-printing technology, for research underscores the crucial need to develop robust biobased materials with excellent printing quality and reproducibility. The main focus of this study is to prepare and characterize some composite gels obtained with a low-molecular-weight gelling (LMWG) peptide called Fmoc-diphenylalanine (Fmoc-FF) and two types of cellulose nanofibrils (CNFs). The so-called Fmoc-FF peptide has the ability to self-assemble into a nanowire shape and therefore create an organized network that induces the formation of a gel. Despite their ease of preparation and potential use in biological systems, unfortunately, those Fmoc-FF nanowire gel systems cannot be 3D printed due to the high stiffness of the gel. For this reason, this study focuses on composite materials made of cellulose nanofibrils and Fmoc-FF nanowires, with the main objective being that the composite gels will be suitable for 3D printing applications. Two types of cellulose nanofibrils are employed in this study: (1) unmodified pristine cellulose nanofibrils (uCNF) and (2) chemically modified cellulose nanofibrils, which ones have been grafted with polymers containing the Fmoc unit on their backbone (CNF-
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