1,2-Bis-Triazenylarenes Enable Vicinal Sandmeyer-Type Reactions.

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Tác giả: Carl Thomas Bormann, Farzaneh Fadaei-Tirani, Alexandre Genoux, Anastasia Yu Gitlina, Christeena Mathew, Kay Severin

Ngôn ngữ: eng

Ký hiệu phân loại: 220.5201 Modern versions and translations

Thông tin xuất bản: Germany : Angewandte Chemie (International ed. in English) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 718096

The introduction of two nucleophiles in the vicinal position of arenes via Sandmeyer-type reactions is compromised by the problematic diazotization of ortho-diaminoarenes. Herein, it is shown that vicinal substitution reactions are facilitated by the use of 1,2-bis-triazenylarenes. Two distinct methodologies for the synthesis of these triazenes are presented. The first approach involves the sequential conversion of 1-amino-2-iodoarenes into first mono- and then bis-triazenylarenes. The second procedure is based on Ru-catalyzed [2 + 2 + 2] cycloaddition reactions between diynes and a 1,2-bis-triazenylalkyne. The two triazene groups in the products can be substituted sequentially by a range of nucleophiles including fluoride, chloride, bromide, iodide, azide, hydroxide, methoxide, and acetamide.
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