A Controlled Single-Centre Pilot Study to Evaluate the Effect of Prophylactic Surgery in Asymptomatic Degenerative Cervical Cord Compression.

• Tác giả: Josef Bednarik, Richard Chaloupka, Tomas Horak, Magda Horakova, Zdenek Kadanka, Milos Kerkovsky, Karel Maca, Dusan Matejicka, Martin Nemec, Tomas Rohan, Ludek Ryba, Eva Vlckova
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Global spine journal , 2025
• Bộ sưu tập: NCBI
• ID: 718108

Tóm tắt

 Study DesignSingle-centre controlled pilot study.ObjectivesTo evaluate the effect of prophylactic surgery and to review the biases of a therapeutic trial in asymptomatic degenerative cervical cord compression (ADCC) patients.MethodsPatients with ADCC and at least 1 predictor of progression to symptomatic degenerative cervical cord myelopathy (DCM) were offered either prophylactic surgery or standard structured rehabilitation. Recruited patients were clinically followed to detect the development of symptomatic DCM.ResultsForty-one patients treated surgically and 68 patients treated non-surgically completed the minimum 36 months' follow-up
  3 recruited patients were lost from evaluation. The surgical group had a higher Neck Disability Index score and more severe MRI compression. A matched subgroup of 41 non-surgical patients was created to reduce potential bias. During the follow-up period we observed progression to symptomatic DCM in 1 surgical case (2.4%) compared to 9 patients in the non-surgical group (13.2%,