INTRODUCTION AND IMPORTANCE: Bone metastases are common in advanced malignancies, particularly from breast and prostate cancers, leading to significant morbidity due to pain, functional impairment, and skeletal-related events. This case report discusses a multidisciplinary approach using minimally invasive techniques for managing a challenging supracetabular metastatic lesion. CASE PRESENTATION: A 46-year-old female with metastatic bone disease in the right supracetabular pelvic region secondary to primary breast cancer presented with severe pain (Numeric Analog Scale [NAS] 7-8) and functional impairment. Systemic bisphosphonate therapy with zoledronic acid was initiated. The patient underwent a combination of percutaneous radiofrequency ablation (RFA), osteoplasty, and cementoplasty under C-arm guidance. Medium-viscosity acrylic cement was injected to stabilize the lesion post-ablation. CLINICAL DISCUSSION: The procedure was successful, with significant pain relief (NAS reduced to 3-4) and improved functional stability. The patient experienced rapid recovery with minimal complications and reduced analgesic requirement. This case highlights the efficacy of combining RFA and cementoplasty for localized management of osteolytic metastatic lesions. RFA provided cytotoxic tumor ablation, while cementoplasty reinforced bone structure and contributed to additional pain relief. The outcomes align with existing literature demonstrating the benefits of these techniques in reducing pain and improving quality of life. CONCLUSION: Minimally invasive interventions such as RFA and cementoplasty are effective in managing symptomatic bone metastases, offering a viable alternative to traditional surgical methods. This approach underscores the importance of integrating systemic and localized therapies in advanced cancer care.