PPM1D ameliorates Alzheimer's disease by promoting mitophagy.

• Tác giả: Jian Gong, Xiaohong Sun, Aiming Wang, Fan Zhang, Wenqiang Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.831 *Alzheimer disease
• Thông tin xuất bản: United States : Experimental neurology , 2025
• Bộ sưu tập: NCBI
• ID: 718625

Tóm tắt

Mitochondrial autophagy (mitophagy) plays an essential role in the maintenance of mitochondrial homeostasis. Defective mitophagy triggered by amyloid beta (Aβ) is linked to neuronal deterioration and neurodegeneration in Alzheimer's disease (AD). However, the molecular mechanism underlying the defective mitophagy in AD is still not fully illustrated. Protein phosphatase Mn