Relationship between Sputum Bacterial Load and Lung Function in Children with Cystic Fibrosis Receiving Tobramycin.

• Tác giả: Gwee A, Lei A, Satzke C, Pell Cl, Rogers Gb, Sandaradura I, Harwood Kh, Robinson P, Duffull S, Ranganathan S, Shanthikumar S, Manning Sk, Taylor Sl, Lai T
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: England : Respiratory medicine , 2025
• Bộ sưu tập: NCBI
• ID: 718850

Tóm tắt

 BACKGROUND: Chronic pulmonary infection with pathogens such as Pseudomonas aeruginosa is associated with lung function decline and increased mortality in people with cystic fibrosis (CF). The relationship between sputum bacterial load and the severity of pulmonary exacerbations remains unclear. This study aimed to explore the relationship between sputum bacterial load and clinical response to antibiotic treatment of pulmonary exacerbations in children with CF. METHODS: Multicentre prospective longitudinal study of children with CF receiving IV tobramycin for a pulmonary exacerbation and who had prior isolation of Gram-negative bacteria and able to expectorate sputum. Lung function (FEV RESULTS: Twelve children (14 admissions) were enrolled and each provided ≥2 sputum samples
  11 children (13 admissions) also had ≥2 FEV CONCLUSION: A greater reduction in total sputum P. aeruginosa bacterial load (live+dead) was associated with improved lung function (FEV