Orthobiologics represent a rapidly advancing field of research in musculoskeletal care, providing novel therapies to modify symptoms and potentially augment tissue regeneration when used in the clinical or operative setting. These treatments are derived from autologous cells, tissues, and blood components, yielding bioactive elements that may promote healing, reduce symptoms and be associated with improved patient outcomes. Biologic therapies such as platelet-rich plasma, bone marrow aspirate concentrate, adipose-derived products, and amniotic allograft tissues have demonstrated favorable clinical outcomes. The Journal of Arthroscopy and its companion journals are committed to advancing the field by publishing high-quality, peer-reviewed orthobiologics research. This anthology of articles showcases significant recent advancements in musculoskeletal orthobiologics research.