Effect of Intermittent Hypoxemia and Hyperoxemia during the Neonatal Period on Control of Breathing Function among Infants Born Extremely Preterm.

• Tác giả: Ana Cecilia Aguilar, Eduardo Bancalari, Nelson Claure, Alaleh Dormishian, Deepak Jain, Alini Schott, Jose Tolosa
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : The Journal of pediatrics , 2025
• Bộ sưu tập: NCBI
• ID: 718885

Tóm tắt

OBJECTIVE: To evaluate the association between intermittent hypoxemia (IH) and hyperoxemia (HOX) during the first 28 days with peripheral and central chemoreception at 36 weeks postmenstrual age among infants born extremely preterm. STUDY DESIGN: For this observational study 52 infants born at 23 to 28 weeks of gestational age were enrolled. Mean daily IH frequency (SpO RESULTS: Multivariable generalized linear models showed increasing IH and HOX were independently associated with an attenuated ventilatory response to 100% O CONCLUSIONS: In these infants born extremely preterm, neonatal intermittent hypoxemia and hyperoxemia were independently associated with attenuated peripheral chemoreception at near term corrected age. This may reflect reduced peripheral chemoreceptor oxygen sensitivity and may be in part responsible for persistence of respiratory instability in infants born preterm. Neonatal intermittent hypoxemia or hyperoxemia were not associated with reduced central chemoreception.