This study reports the isolation of 11 previously undescribed sesquiterpenoids from the root bark of Lycium chinense Mill, including a 1,10-secoeudesmane-type sesquiterpene (1), a 9,10-secoeudesmane-type sesquiterpene (2) and nine rearranged eudesmane sesquiterpenes (3-11). Structures elucidation of these compounds was established using 1D/2D NMR, electronic circular dichroism calculations along with DP4