Loss of aryl hydrocarbon receptor reduces pancreatic tumor growth by increasing immune cell infiltration.

• Tác giả: Samaneh S Åhrling, Paola Cappello, Hani Choksi, Zilvinas Dambrauskas, Siddhartha Das, Landon J Edgar, Paolo Giuliana, Denis M Grant, Antanas Gulbinas, Fauzia N Izzati, Kristaps Jaudzems, Vinicius Kannen, Toivo Maimets, Jason Matthews, Ninni E Olafsen, Indrek Teino
• Ngôn ngữ: eng
• Ký hiệu phân loại: 912.01 Philosophy and theory
• Thông tin xuất bản: England : Biochemical pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 718999

Tóm tắt

 Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease which remains poorly understood. Increasing evidence suggests that the aryl hydrocarbon receptor (AHR) plays a role in the pathogenesis of several cancers
  however, its role in PDAC is unclear because AHR exhibits both pro- and anti-tumor activities. Here we evaluated the role of AHR in CR705 and K8484 murine PDAC cells in vitro and CR705 cells in vivo. Loss of Ahr did not affect cell proliferation compared with Cas9 control cells and no differences in tumor development between CR705