Supplementation with the Probiotic Strains Bifidobacterium longum and Lactiplantibacillus rhamnosus Alleviates Glucose Intolerance by Restoring the IL-22 Response and Pancreatic Beta Cell Dysfunction in Type 2 Diabetic Mice.

• Tác giả: Yukyung Choi, Eun-Hee Doo, Chul Sung Huh, Byoung Kook Kim, Heebal Kim, Kyunghwan Kim, Myunghoo Kim, Won Jun Kim, Ri Ryu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: United States : Probiotics and antimicrobial proteins , 2025
• Bộ sưu tập: NCBI
• ID: 719065

Tóm tắt

 Type 2 diabetes (T2D) is known as adult-onset diabetes, but recently, T2D has increased in the number of younger people, becoming a major clinical burden in human society. The objective of this study was to determine the effects of Bifidobacterium and Lactiplantibacillus strains derived from the feces of 20 healthy humans on T2D development and to understand the mechanism underlying any positive effects of probiotics. We found that Bifidobacterium longum NBM7-1 (Chong Kun Dang strain 1
  CKD1) and Lactiplantibacillus rhamnosus NBM17-4 (Chong Kun Dang strain 2
  CKD2) isolated from the feces of healthy Korean adults (n = 20) have anti-diabetic effects based on the insulin sensitivity. During the oral gavage for 8 weeks, T2D mice were supplemented with anti-diabetic drugs (1.0-10 mg/kg body weight) to four positive and negative control groups or four probiotics (200 uL
  1 × 10