In 2021, China Castleman Disease Network (CDCN) published the the first consensus of the diagnosis and treatment of Castleman disease in China (2021 ). In recent years, significant progress has been made in the field of Castleman disease. Based on the most up-to-date research findings and through collective discussion of CDCN experts, the new guideline is developed according to the Oxford Center for Evidence-Based Medicine (OCEBM) levels of evidence system, building upon the aforementioned consensus.