Detection of CRISPR/Cas9-Mediated Fetal Hemoglobin Reactivation in Erythroblasts Derived from Cord Blood-Hematopoietic Stem Cells.

• Tác giả: Mehdi Banan, Hamid Reza Khorram Khorshid, Masoumeh Sadat Mousavi Maleki, Nahal Maroofi, Younes Modaberi, Reza Najafipour, Mahsa Tahmasebi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.59012 *Greece
• Thông tin xuất bản: Switzerland : Molecular biotechnology , 2025
• Bộ sưu tập: NCBI
• ID: 719307

Tóm tắt

Reactivation of the fetal hemoglobin (HbF) in adult erythroid cells via genome editing is a strategy for the treatment of β-thalassemia and sickle cell disease. In related reports, the reactivation of HbF is regularly examined in erythroblasts which are generated from the adult CD34