The prevalence and risk factors associated with zinc deficiency after pancreatic surgery.

• Tác giả: Katsuya Ami, Keiko Kamei, Dongha Lee, Ippei Matsumoto, Takaaki Murase, Takuya Nakai, Masaya Nakano, Chihoko Nobori, Atsushi Takebe, Yoshifumi Takeyama, Yuta Yoshida
• Ngôn ngữ: eng
• Ký hiệu phân loại: 583.34 *Ranunculales (Ranales)
• Thông tin xuất bản: Japan : Surgery today , 2025
• Bộ sưu tập: NCBI
• ID: 719464

Tóm tắt

 PURPOSE: To clarify the prevalence, risk factors, and clinical implications associated with zinc deficiency in patients undergoing pancreatic surgery. METHODS: The serum zinc levels were measured in 329 patients post-pancreatic surgery between January and April 2021. The postoperative serum zinc levels and clinicopathological variables were retrospectively analyzed. RESULTS: The median serum zinc level was 73 µg/dL (33-218). Zinc deficiency (zinc level <
  60 µg/dL) was observed in 52 patients (16%). A total of 329 patients were classified into zinc-deficient (n = 52) and non-deficient (zinc ≥ 60 µg/dL, n = 277) groups. A univariate analysis revealed significant differences in sex, postoperative body mass index, serum albumin, total cholesterol, creatinine, aspartate aminotransferase (AST), HbA1c levels, diabetes, surgical procedures, and operative blood loss. According to a multivariate analysis, male sex [odds ratio (OR) 3.70
  95% confidence interval (CI) 1.67-8.20
  p = 0.001], postoperative serum albumin levels <
  3.9 g/dL (OR 6.39
  95% CI 3.30-12.37
  p <
  0.001), postoperative serum AST ≥ 51 U/L (OR, 4.6
  95% CI 0.07-0.29
  p <
  0.001), and total pancreatectomy (OR 3.68
  95% CI 1.37-9.85
  p = 0.009) were found to be independent predictors of zinc deficiency after pancreatic surgery. CONCLUSIONS: Zinc deficiency frequently occurs in patients undergoing pancreatic surgery. Lower postoperative zinc levels could be linked to sex, the serum albumin and AST levels, and surgery type.