Pregnancy in women with mitochondrial disease-A literature review and suggested guidance for preconception and pregnancy care.

• Tác giả: Ali Buckland, John Christodoulou, Michael C Fahey, Pema Hayman, Lisa Hui, David A Mackey, Andrew J Mallett, Daniel R Schweitzer, Clare P Stuart, Wai Yan Yau
• Ngôn ngữ: eng
• Thông tin xuất bản: Australia : The Australian & New Zealand journal of obstetrics & gynaecology , 2025
• Bộ sưu tập: NCBI
• ID: 719567

Tóm tắt

 Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women. We conducted a systematic literature review on mitochondrial disease in pregnancy
  five cohort studies and 19 case reports were included. For many women with mitochondrial disease, pregnancy does not have a negative effect on health status. However, serious adverse outcomes may occur. We provide suggested guidelines for preconception counselling and antenatal care.