Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology.

• Tác giả: Pablo Aguilar-Dominguez, Muge Akinci, Eider M Arenaza-Urquijo, Kaj Blennow, Carles Falcon, Karine Fauria, Juan Domingo Gispert, Oriol Grau-Rivera, Gwendlyn Kollmorgen, Gregory Operto, Eleni Palpatzis, Clara Quijano-Rubio, Marc Suárez-Calvet, Clara Vila-Castelar, Henrik Zetterberg
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.2507 Motor land vehicles, cycles
• Thông tin xuất bản: England : Molecular psychiatry , 2025
• Bộ sưu tập: NCBI
• ID: 719883

Tóm tắt

Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by sex/gender among cognitively unimpaired older adults at increased risk of developing AD. We included 397 participants from the ALFA+ cohort with CSF Aβ