High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL.

• Tác giả: Christophe Antoniewski, Paola Ballerini, Lea Bellenger, Julien Calvo, Baptiste Gaillard, Florian Gilain, Anthony Kypraios, Helene Lapillonne, Stéphane Jc Mancini, Tony Marchand, Irina Naguibneva, Arnaud Petit, Jean-François Peyron, Françoise Pflumio, Laurent Renou, Benjamin Uzan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 599.26 *Peramelina (Bandicoots)
• Thông tin xuất bản: England : Leukemia , 2025
• Bộ sưu tập: NCBI
• ID: 720156

Tóm tắt

T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy characterized by increased proliferation and incomplete maturation of T-cell progenitors, for which relapse is often of poor prognosis. To improve patient outcomes, it is critical to understand the chemoresistance mechanisms arising from cell plasticity induced by the bone marrow (BM) microenvironment. Single-cell RNA sequencing of human T-ALL cells from adipocyte-rich and adipocyte-poor BM revealed a distinct leukemic cell population defined by quiescence and high CD44 expression (Ki67