BACKGROUND: Pharmacist prescribing legislation aims to enhance healthcare quality and accessibility. However, in many countries, like the Netherlands, it has not yet been legally established. AIM: To investigate pharmacists' perspectives on potential pharmacist prescribing in the Netherlands. METHOD: An online survey using a questionnaire that was distributed via e-mail and electronic newsletters to most practicing pharmacists in the Netherlands during October and November 2023. The questionnaire was based on previous literature, further developed during an international conference with pharmacists and piloted with Dutch pharmacists. Agreement with statements about potential prescribing models, settings, preconditions, and perceived benefits and risks was measured using a 4-point Likert scale. Data were analysed descriptively. RESULTS: In total, 625 participants from community pharmacy (n = 432
69.1%), hospital pharmacy (n = 149
23.8%), or other/combined settings (n = 44
7.0%) completed the questionnaire. Most pharmacists (somewhat) agreed with the introduction of an independent prescribing model with limitations (n = 538
86.1%) or a model dependent on collaborative agreements with physicians (n = 471
75.4%). A minority (n = 245
39.2%) supported independent prescribing with diagnostic authority. The precondition that participants most frequently (somewhat) agreed with was access to health records (n = 607
97.1%). The most (somewhat) agreed-upon benefits were enhanced professional position of pharmacists (n = 574
91.8%) and reduced workload for other prescribers (n = 573
91.7%). Increased workload for pharmacists (n = 495
79.2%) was the most (somewhat) agreed-upon identified risk. CONCLUSION: Pharmacists in the Netherlands are generally supportive of an independent but limited or collaborative pharmacist prescribing model. These findings support further investigations into the potential introduction of pharmacist prescribing legislation.