AIMS: This study aimed to evaluate image quality, myocardial perfusion, and diagnostic performance of a novel [ METHODS AND RESULTS: Forty-seven patients with suspected or known coronary artery disease (CAD) were prospectively enrolled to undergo one-day rest/ATP-stress XTR004 and NH CONCLUSION: XTR004 PET MPI demonstrated promising image quality, diagnostic certainty and myocardial perfusion characteristics comparable to NH