The nitrogenase mechanism: new roles for the dangler?

• Tác giả: Douglas C Rees, Rebeccah A Warmack
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: Germany : Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 720376

Tóm tắt

Dangler sites protruding from a core metallocluster were introduced into the bioinorganic lexicon in 2000 by R.D. Britt and co-workers in an analysis of the tetramanganese oxygen-evolving cluster in photosystem II. In this perspective, we consider whether analogous dangler sites could participate in the mechanism of dinitrogen reduction by nitrogenase. Two possible roles for dynamic danglers in the active site FeMo cofactor are highlighted that might occur transiently during turnover. The first role for a dangler involves the S2B belt sulfur associated with displacement by carbon monoxide and other ligands, while the second dangler role could involve the entire cluster upon displacement of the His-