Influence of dosimetry accuracy on the correlation with treatment outcome in a preliminary PSMA radiopharmaceutical therapy study.

• Tác giả: Ali Afshar-Ormieh, Carlos Vinicius Gomes, Jiaxi Hu, Sofia Karkampouna, Axel Rominger, Robert Seifert, Kuangyu Shi, Song Xue
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.32259 Personnel management (Human resource management)
• Thông tin xuất bản: Germany : European journal of nuclear medicine and molecular imaging , 2025
• Bộ sưu tập: NCBI
• ID: 720409

Tóm tắt

 INTRODUCTION: Despite the potential of dosimetry in optimizing personalized radiopharmaceutical therapy (RPT), its limited clinical implementation impedes the development of simplified protocols for routine adoption. However, simplifications may introduce errors in dosimetry, prompting questions about their impact on clinical practice. MATERIALS AND METHODS: In this retrospective study, we analyzed data from 21 patients diagnosed with metastatic castration-resistant prostate cancer (mCRPC) who underwent multiple cycles of RESULTS: STPD showed a non-significant difference in correlation with PSA decline rate, despite a mean percentage error (MPE) of up to 36.44% in tumor dosimetry compared to MTPD (MTPD: rho = -0.39, p <
  0.001
  STPD: rho = -0.46, p <
  0.001
  Z = 0.58, p = 0.56). Both STPD CONCLUSION: The preliminary findings from a small cohort indicate that the reduced accuracy of a clinically simplified protocol may not diminish the clinical therapy outcome predictive value of dosimetry. Future thorough systematic investigations may be needed to determine the clinically acceptable level of accuracy for dosimetry.