Efficient radiolabeling of mesoporous silica nanoparticles for single-cell PET imaging.

• Tác giả: David Anders, Neeladrisingha Das, Syamantak Khan, Arutselvan Natarajan, Guillem Pratx, Jung Ho Yu, Xiaoxu Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 294.3823 Buddhism
• Thông tin xuất bản: Germany : European journal of nuclear medicine and molecular imaging , 2025
• Bộ sưu tập: NCBI
• ID: 720526

Tóm tắt

 PURPOSE: Nanoparticles are highly efficient vectors for ferrying contrast agents across cell membranes, enabling ultra-sensitive in vivo tracking of single cells with positron emission tomography (PET). However, this approach must be fully characterized and understood before it can be reliably implemented for routine applications. METHODS: We developed a Langmuir adsorption model that accurately describes the process of labeling mesoporous silica nanoparticles (MSNP) with RESULTS: We found that highly porous mesoporous nanoparticles (d = 100 nm) with MCM-41 pore structures can achieve radiolabeling efficiency >
  30 GBq/mg using CONCLUSION: We characterized the critical parameters of MSNP-mediated direct cellular radiolabeling to improve the use of these nanoparticles as cellular labels for highly sensitive preclinical PET imaging.