Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation.

• Tác giả: Benjamin R Arenkiel, Jonathan C Bean, Megan E Burt, Kristine M Conde, Yue Deng, Shuzheng Fang, Xing Fang, Olivia Z Ginnard, Junying Han, Yang He, Sanika V Jossy, Yongxiang Li, Hailan Liu, Hesong Liu, Qingzhuo Liu, Yuhan Shi, Qingchun Tong, Longlong Tu, Chunmei Wang, Mengjie Wang, HueyZhong Wong, Yong Xu, Yongjie Yang, Yuxue Yang, Na Yin, Meng Yu
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Metabolism: clinical and experimental , 2025
• Bộ sưu tập: NCBI
• ID: 720544

Tóm tắt

Obesity is a growing global health epidemic with limited orally administered therapeutics. Serotonin (5-HT) is one neurotransmitter which remains an excellent target for new weight-loss therapies, but a gap remains in understanding the mechanisms involved in 5-HT produced in the dorsal Raphe nucleus (DRN) and its involvement in meal initiation. Using an optogenetic feeding paradigm, we showed that the 5-HT