Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes.

• Tác giả: John S D Chan, Janos G Filep, Marie-Josée Hébert, Julie R Ingelfinger, Daniel N Leal, Min-Chun Liao, Kana N Miyata, Junzheng Peng, Ke Su, Michifumi Yamashita, Wen-Xia Yang, Shao-Ling Zhang, Jing Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.32259 Personnel management (Human resource management)
• Thông tin xuất bản: United States : Diabetes , 2025
• Bộ sưu tập: NCBI
• ID: 720695

Tóm tắt

Renin-angiotensin system (RAS) activation plays an important role in the progression of diabetic kidney disease (DKD). However, systemic RAS blockade alone is insufficient to reverse DKD progression. We hypothesized that intrarenal renin-angiotensin system (iRAS) activation plays a crucial role in the progression of DKD. We sought to elucidate the role of the iRAS in DKD progression. Selective deletion of angiotensinogen in renal tubules ameliorated the pathological features of DKD. Our study indicates that iRAS inactivation may be a potential approach for preventing DKD disease severity and its progression.