JMJD8 Regulates Adipocyte Hypertrophy Through the Interaction With Perilipin 2.

• Tác giả: Sona Kang, Dongjoo You
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Diabetes , 2025
• Bộ sưu tập: NCBI
• ID: 720937

Tóm tắt

New research builds on previous findings that JMJD8 mediates insulin resistance by promoting adipocyte hypertrophy. We identified PLIN2 as a binding partner of JMJD8 using proteomics approaches. This study reveals a physical interaction between JMJD8 and PLIN2, which plays a crucial role in driving adipocyte hypertrophy and insulin resistance. JMJD8 suppresses fasting-induced lipophagy and reduces energy production by inhibiting PLIN2 phosphorylation. These findings highlight the importance of JMJD8 and PLIN2 in regulating lipid droplet homeostasis and suggest a potential mechanism for controlling fat mobilization during energy deprivation.