Differential effects of endo- and exopolyphosphatase expression on the induction of the mitochondrial permeability transition pore.

• Tác giả: Yaw Akosah, Vedangi Hambardikar, Sally Morris, Maria Neginskaya, Evgeny V Pavlov, Maria E Solesio
• Ngôn ngữ: eng
• Ký hiệu phân loại: 610.736 Long-term care nursing
• Thông tin xuất bản: Netherlands : Biochimica et biophysica acta. Biomembranes , 2025
• Bộ sưu tập: NCBI
• ID: 720945
• Chủ đề: 1. Differential; 2. Effects; 3. Of

Tóm tắt

Inorganic polyphosphate (polyP) is a polymer that consists of a series of orthophosphates connected by high-energy phosphoanhydride bonds, like those found in ATP. In mammalian mitochondria, polyP has been linked to the activation of the mitochondrial permeability transition pore (mPTP). However, the details of this process are not completely understood. The activation of mPTP by polyP may involve the regulation of bioenergetics, Ca