Rnd3 Ameliorates Diabetic Cardiac Microvascular Injury via Facilitating Trim40-Mediated Rock1 Ubiquitination.

• Tác giả: Xinchun Dai, Yu Duan, Wen Ge, Mengyuan Jiang, Jie Lin, Huanhuan Qiang, Dongdong Sun, Jiye Zhang, Xiao Zhang, Xiaohua Zhang, Xuebin Zhang, Yan Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Diabetes , 2025
• Bộ sưu tập: NCBI
• ID: 720986

Tóm tắt

Impaired cardiac microvascular function is a significant contributor to diabetic cardiomyopathy. Rnd3 expression is notably downregulated in cardiac microvascular endothelial cells under diabetic conditions. Rnd3 overexpression mitigates diabetic myocardial microvascular injury and improves cardiac function through the Rock1/myosin light chain signaling pathway. Rnd3 facilitates the recruitment and interaction with Trim40 to promote Rock1 ubiquitination, thereby preserving endothelial barrier integrity in the diabetic heart.