Molecular miscibility of ASD blend components: an evaluation of (the added value of) solid state NMR spectroscopy and relaxometry.

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Tác giả: Peter Adriaensens, Lennert Cools, Elien Derveaux, Guy Van den Mooter

Ngôn ngữ: eng

Ký hiệu phân loại: 331.1204 Labor force and market

Thông tin xuất bản: United States : Journal of pharmaceutical sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 721055

In order to evaluate the stability of an amorphous solid dispersion (ASD) it is crucial to be able to accurately determine whether the ASD components are homogeneously mixed or not. Several solid-state analysis techniques are at the disposal of the formulation scientist, such as for example modulated differential scanning calorimetry (mDSC) and solid-state nuclear magnetic resonance spectroscopy (ssNMR). ssNMR is a robust, versatile, and accurate analysis technique with a large number of application possibilities. Especially ssNMR relaxometry, which allows the measurement of the proton relaxation times T
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