Precise modelling of mitochondrial diseases using optimized mitoBEs.

• Tác giả: Jiayi Li, Jiwu Ren, Wensheng Wei, Xiaoxu Wei, Zongyi Yi, Ying Yu, Xiaoxue Zhang, Xue Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 922.945 *Hindus
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 721148

Tóm tắt

The development of animal models is crucial for studying and treating mitochondrial diseases. Here we optimized adenine and cytosine deaminases to reduce off-target effects on the transcriptome and the mitochondrial genome, improving the accuracy and efficiency of our newly developed mitochondrial base editors (mitoBEs)