Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase.

• Tác giả: Alyssa Ayala, Baozhi Chen, Nadia Elghobashi-Meinhardt, Xiaofeng Qi, Jian-Ke Tie, Rong Wang, Ning Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 721224

Tóm tắt

γ-Glutamyl carboxylase (GGCX) is the sole identified enzyme that uses vitamin K (VK) as a cofactor in humans. This protein catalyses the oxidation of VK hydroquinone to convert specific glutamate residues to γ-carboxyglutamate residues in VK-dependent proteins (VDPs), which are involved in various essential biological processes and diseases