Extracellular Vesicle-Associated miR-ERIA Exerts the Antiangiogenic Effect of Macrophages in Diabetic Wound Healing.

• Tác giả: Sifan Chen, Xiaodan He, Xiaosi Hong, Weijie Lin, Lifang Mai, Kan Sun, Li Yan, Tingting Zeng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.91 Animal diseases
• Thông tin xuất bản: United States : Diabetes , 2025
• Bộ sưu tập: NCBI
• ID: 721247

Tóm tắt

An understanding of cell interactions is needed to identify therapeutic targets for diabetic cutaneous ulcers. We explored extracellular vesicles after treatment with advanced glycation end products (AGEs-EVs) derived from macrophages that can suppress diabetic cutaneous wound healing. We found that a novel miRNA enriched in AGEs-EVs (miR-ERIA) suppresses the migration and tube formation of vascular endothelial cells by targeting helicase with zinc finger 2. miR-ERIA offers a potential therapeutic target for diabetic cutaneous ulcers.