Homeobox C4 Transcription Factor Promotes Adipose Tissue Thermogenesis.

• Tác giả: Mengxi Jiang, Hang Li, Yi Liu, Fengshou Shi, Yuxuan Wang, Yingting Wu, Jiaqi Xin, Siqi Xu, Ting Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 978.02 1800–1899
• Thông tin xuất bản: United States : Diabetes , 2025
• Bộ sưu tập: NCBI
• ID: 721249

Tóm tắt

Homeobox C4 (HOXC4) links metabolic pathways and correlates inversely with mouse body weight and positively with Ucp1 expression in mouse adipose tissue. Gain- and loss-of-function experiments in mice demonstrated HOXC4's essential role in promoting adipose thermogenesis and providing metabolic benefits. HOXC4 interacts with the nuclear receptor coactivator 1 cofactor via its hexapeptide motif to activate Ucp1 transcription, revealing a novel mechanism of thermogenic gene regulation.