INTRODUCTION: Interest has grown in optimizing radical prostatectomy (RP) pathways for prostate cancer, and RP has been removed from the Centers for Medicare & Medicaid Services inpatient-only list. We aim to determine national trends in outpatient RP. METHODS: The National Inpatient Survey and Nationwide Ambulatory Surgery Survey were queried to categorize RPs between 2016 and 2020 as inpatient RP and outpatient RPs, comprising same-day discharge (SDD) and ambulatory encounters. Trends in outpatient RP over time were analyzed. Multivariable logistic regression analysis identified factors associated with SDD. Multivariable generalized linear models were used to compare total hospital charges between SDD and inpatient RPs. RESULTS: In a cohort of 362,123 RPs from 2016 to 2020, outpatient RPs increased from 4.8% to 53.7% ( CONCLUSIONS: Over 50% of RPs are now performed as ambulatory or SDD encounters. SDD RP is more common in high-volume facilities with lower bed counts. Although our data suggest lower hospital charges, further study is warranted to evaluate the impact of SDD on readmission rates and direct patient costs.