Childhood and adolescent melanoma: An update.

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Tác giả: Jane M Grant-Kels, Patrick McMullan

Ngôn ngữ: eng

Ký hiệu phân loại: 616.91852 Other diseases

Thông tin xuất bản: United States : Clinics in dermatology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 721731

Pediatric melanoma is a rare but clinically significant public health concern, as it accounts for 7% of all malignancies in adolescents aged 15 to 19. Given the overall rarity of pediatric melanoma, especially in preadolescents, patients can go undetected, leading to a delay in treatment. We divide pediatric melanoma subtypes into three distinct age ranges-infantile, preadolescent, and adolescent-and distinguish the clinical features, prognosis, and associated risk factors of each age range. We next summarize the three predominant melanoma subtypes-Spitzoid melanoma, congenital melanocytic nevus-associated melanoma, and conventional (adult-type) melanoma-and provide distinguishing clinical, histologic, and genetic features from their difficult-to-differentiate benign counterparts. We conclude by reviewing consensus guidelines for pediatric melanoma staging and treatment, with a special emphasis on outlining barriers to adapting the advancements in targeted therapeutics into the standard care of pediatric melanoma.
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