A microRNA-regulated transcriptional state defines intratumoral CD8

• Tác giả: Z Busra Agir, Cindy Barba, Ben Battistone, Kaylyn M Bauer, Ellen J Beswick, Micah J Drummond, H Atakan Ekiz, Muhammad Zaki Hidayatullah Fadlullah, Arevik Ghazaryan, Colton Hernandez, Soh-Hyun Lee, Morgan C Nelson, Ryan M O'Connell, Dinesh Rao, June L Round, Aik C Tan, William W Tang, Jacob Tantalla, Amber Thibeaux, Van B Tran, Emmanuel Stephen Victor, Warren P Voth, Allison M Weis, Matthew Williams
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.1344 Aerospace engineering
• Thông tin xuất bản: United States : Cell reports , 2025
• Bộ sưu tập: NCBI
• ID: 721987

Tóm tắt

The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8