Effects of EMD57033, an activator of actomyosin ATPase activity, on the relaxation process of cell membrane-permeabilized carotid artery and taenia cecum from guinea pigs.

• Tác giả: Yasuyuki Naraki, Masaru Watanabe
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: Japan : Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi , 2025
• Bộ sưu tập: NCBI
• ID: 722006

Tóm tắt

Smooth muscle relaxation after contraction is thought to reflect "latch-like" slow cycling bridge formation and deformation. However, how actin-myosin interaction contributes to the transfer from fast-cycling cross bridges to slow-cycling bridges is still unclear. The thiadiazinone compound EMD57033 is known to bind to an allosteric pocket in the myosin motor domain and to increase basal and actin-activated myosin ATPase activity and contractile force in striated muscles. Therefore, we investigated whether EMD57033 affected the relaxation process after Ca