KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31.

• Tác giả: Chen Dong, Hu Gan, Hong-Xu Li, Dandan Lin, Xin Shuai, Wei Wang, Ci Yang, Bo Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 265.64 Absolution
• Thông tin xuất bản: United States : Developmental cell , 2025
• Bộ sưu tập: NCBI
• ID: 722032
• Chủ đề: 1. Kras4b; 2. Oncogenic; 3. Mutants

Tóm tắt

Kirsten rat sarcoma viral oncogene homolog (KRAS) oncogenic mutations are genetic drivers in various cancers, including non-small cell lung cancer (NSCLC). However, the regulatory mechanisms underlying the progression of NSCLC driven by oncogenic KRAS mutants are incompletely understood. Here, we show that ubiquitin specific peptidase 25 (USP25) impedes ring finger protein 31 (RNF31)-mediated linear ubiquitination of KRAS oncogenic mutants (KRAS