BACKGROUND: This study aimed to evaluate whether oxygenation levels (PaO METHODS: We prospectively collected data over 30 mo from patients with proximal occlusion of the anterior circulation treated with successful EVT under general anesthesia. After the procedure, patients were admitted to the ICU for delayed extubation. Two groups were established based on the partial pressure of oxygen (PaO RESULTS: During the study period, 271 patients were admitted to our ICU after EVT for AIS. Of these, 210 patients met the inclusion criteria. No significant differences were found between the groups in demographics, clinical factors, neurological status, or functional outcomes at 3 mo. The primary outcome showed no significant difference: 48 of 100 patients (48%) in the PaO CONCLUSION: No association was found between 3-mo functional outcomes and post-procedure oxygenation levels in patients with AIS treated successfully with EVT under general anesthesia.