Major depressive disorder (MDD) is prevalent worldwide, substantially and negatively impacting both the quality and length of life of 280 million people globally. The genetic risk factors of MDD have been studied in various previous research, but the findings lack consistency. Sex/gender and racial/ethnic disparities have been reported
however, many previous genetic studies, represented by large-scale genome-wide association studies (GWASs) are known to lack diversity in the study cohorts. All of Us is a biorepository aiming to focus on the historically underrepresented groups. We perform GWASs for the MDD phenotype, using over 200,000 participants' genotypes and carry out sex- and racial/ethnic-specific subgroup studies. We identified a risk locus (chr6:151945242) in Estrogen Receptor Alpha Gene (ESR1) (p =