The use of injectable liquid silicone (ILS) in the travesti and trans population poses a public health challenge in Argentina and worldwide. Although ILS and other unauthorized polymers represent a significant risk for this population, there is no consensual and effective approach, nor has the issue been addressed through health policy. This study aimed to explore the experiences of healthcare professionals from various specialties and levels of care regarding the use, management, and treatment of ILS-related complications in trans and travesti individuals. Between August and December 2023, a qualitative, exploratory and descriptive study was carried out with 14 semi-structured interviews with health professionals from four Argentine provinces. According to their accounts, ILS users constitute a population facing multiple vulnerabilities, resorting to these practices due to the immediacy of results and the barriers to accessing safe gender-affirming procedures. Professionals agree on the lack of information and guidelines for addressing ILS-related complications, particularly in managing chronic pain. Furthermore, ILS use is identified as a public health issue requiring an intersectoral and interdisciplinary approach.