Photodynamic therapy (PDT) is a promising approach for treating infections caused by antibiotic-resistant microorganisms. This case report discusses the successful use of PDT in conjunction with antibiotics to treat a persistent scalp abscess in a patient. After multiple failed antibiotic treatments, PDT was introduced, resulting in significant improvement and eventual resolution of the infection. PDT was performed using a formulation of methylene blue in an oily base at 0.05%, applied intralesionally with an 18G cannula and also topically, followed by exposure to red LED light at 50 J/cm². The treatment resulted in the resolution of the infection after two sessions. This case highlights the potential of PDT as an adjunctive therapy in managing complex skin infections, reducing persistent inflammation, and combating bacterial resistance. Additionally, PDT is suggested as a preventive measure in the immediate postoperative period to avoid late complications that might require antibiotics, thereby reducing the risk of developing microbial resistance. Future studies should explore photosensitizers that do not cause skin staining, as can occur with methylene blue, particularly on the face.