Preβ1-high-density lipoprotein binds to TG-rich lipoproteins and its release is impaired in the postprandial state among patients with poorly controlled type 2 diabetes.

• Tác giả: Yoshifumi Fukushima, Satoshi Hirayama, Atsushi Hori, Yuna Horiuchi, Yuri Ichikawa, Katsuo Kubono, Takashi Miida, Utako Seino, Kazumasa Sekihara, Satoshi Soda, Tsuyoshi Ueno
• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.5672 Miscellaneous chemicals
• Thông tin xuất bản: England : Annals of clinical biochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 722779

Tóm tắt

BackgroundAlthough preβ1-high-density lipoprotein (preβ1-HDL) promotes cholesterol efflux, high fasting preβ1-high-density lipoprotein levels after breakfast are reduced in patients with poorly controlled type 2 diabetes.ObjectiveThis study investigated whether preβ1-high-density lipoprotein binds to triglyceride (TG)-rich lipoproteins (TGRLs) in the postprandial state and is released during lipolysis.MethodsWe measured preβ1-high-density lipoprotein concentrations, lecithin-cholesterol acyltransferase (LCAT) activity, and LCAT-dependent preβ1-high-density lipoprotein conversion before and after breakfast in patients with diabetes. We also performed