Nursing science as an academic discipline in Germany is still developing and has not yet been sufficiently integrated into acute hospital care. The aim of this paper is to analyze the key challenges of nursing research in acute hospital care and to develop strategic solutions to strengthen the development of nursing science in Germany. The results of a two-day scoping workshop with national and international experts indicate that the lack of structural integration of nursing science into clinical care, the low number of academically qualified nursing professionals, and insufficient research funding are major obstacles to further development. Based on a SWOT analysis, six priority action areas were identified: (1) development and implementation of qualification and career programs, (2) promotion of clinician scientists, (3) strengthening visibility and communication, (4) effective political participation, (5) increase of research funding, and (6) improvement of networks and collaborations. The implementation of these strategies will contribute to establishing nursing science as an independent discipline, increasing its societal relevance, and promoting evidence-based nursing practice in inpatient acute care. Close collaboration among academia, policymakers, and practitioners is essential for achieving these goal.